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Patients with type 2 diabetes, prediabetes, or those taking antidiabetic medications should inform their provider before adding berberine to a GLP-1 regimen

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These are some of the main situations in which it is advisable to avoid L-carnitine supplementation or to use it only under supervision

Because GLP-1-induced weight loss often includes muscle mass loss (lean body mass), experts generally recommend consuming 0.7 to 1.0 grams of protein per pound of body weight (or as advised by a dietitian) to help preserve muscle