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Currently, the pathogenic mechanisms underlying CCl 4 -induced hepatic injury are not been fully elucidated, but they are likely to be multi-factorial

Whilst study findings seem to not support folate genotype being selected to enhance DNA repair pathways in high UVR environments, the relationship between UVR and folate is proposed to have a role in strengthening our epidermal barrier

Use during pregnancy and lactation should be limited to cases where the benefits outweigh the risks, as high-dose parenteral administration has not been fully studied in these populations