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"Findings were neutral, but less precise for specific subtypes of thyroid cancer, including medullary thyroid cancer, and robust in several additional analyses, including when an alternative comparator group was used," the authors write

In tumor cells, Nrf2 plays an important role in cell proliferation by activating the pentose phosphate pathway (PPP), which provides nucleotides for genomic replication of mitotic tumor cells and the antioxidant NADPH for cytoprotection from oxidative stress provoked by the tumor environment [74]