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large-scale clinical trials are lacking, and findings show dose- and context-dependent variability (U-shaped dose-response curve in some cases)

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doi: 10.3389/fphys.2022.843784 Received 26 December 2021 Accepted 08 February 2022 Published 10 March 2022 Volume 13 - 2022 Edited by Ana Cludia Garcia De Oliveira Duarte, Federal University of So Carlos, Brazil Reviewed by Anand Thirupathi, Ningbo University, China