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These findings indicate that the regulatory effects of distinct miRNAs on CUL5 vary across different tumor types and may be either positive or negative, underscoring the necessity of case-by-case investigation for specific miRNAs

Virofly) through a factorial experiment based on a randomized complete design with three replications

Thus, although age-related low-grade inflammation is a major inducer of STAT3/SOCS3 signaling, it is not only signaling via the cytokine receptors but also that of insulin/IGF-1 receptors which will be inhibited through the signaling of the STAT3/SOCS3 pathway (Fig