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Description

When safety of the study participants and technological developments allow, so called biomarkers can be used to collect PD data to understand if the drug reaches the target, binds to the target and exerts its expected pharmacological activity within the dose range tested

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Death or illness can result from the systemic effects of microbial toxins and pathogens that leak through the intestinal wall and the subsequent immune response that includes the production of inflammatory mediators

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Hung SW, Zhang R, Tan Z, Chung JPW, Zhang T, Wang C

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