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This groove connects to the catalytic cysteine (Cys379) via a short channel, explaining the structural basis for SQORs adaptability to multiple substrates
They target different receptors and were designed to be complementary which is exactly why cagrilintide is studied in combination with an incretin (semaglutide) rather than against one
Unlike other GH secretagogues, it is noted for its selectivity, meaning it primarily stimulates the release of growth hormone without significantly affecting other hormones like cortisol or prolactin, thereby reducing the likelihood of unwanted side effects
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