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GSH regulates mTORC1 signaling and the ISR during cystine starvation Given that cystine and GSH balance are tightly coupled, we next evaluated whether GSH is a modulator of cystine-induced cell signaling

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Most likely reality: microdoses produce small metabolic improvements - subtle visceral fat changes, modest improvements in insulin sensitivity, minor reductions in inflammatory signaling - that compound over time into meaningful clinical benefits

doi:10.1073/pnas.032539299 Wakselman S, Bechade C, Roumier A, Bernard D, Triller A, Bessis A (2008) Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor