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Diarrhea, vomiting, and constipation vary between patients: GI motility changes are a class effect across GLP-1 drugs and retatrutide produces them at a rate consistent with that, with different patients experiencing different patterns depending on their gut baseline and how quickly the dose moves up

102 In patients with CKD, elevated TMAO levels accelerate the decline of renal function and affect long-term survival

found that transplanting a complex microbiota into germ-free mice alleviated the depletion of bone marrow progenitors and restored monocyte proliferation (211)

Increased heart rate : A small increase in resting heart rate has been observed as a class effect with incretin-based therapies