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290 Activated PARP1 also possesses a transcription-regulatory function, promoting the induction of DNA repair factors by E2F1 and enhancing the progression to treatment-resistant cancer

The autophagic pathway moves through multiple steps, including the formation of the phagophore, autophagosome, and eventually, autolysosome where degradation of sequestered substances occurs (Yang and Klionsky, 2010

8.5.4.6 Microencapsulation and spherical crystallization These techniques aim to encapsulate curcumin within micro-sized particles or create spherical agglomerates to improve flowability, compressibility, and dissolution rate, indirectly contributing to better absorption (152)

The application of transcriptomics, animal models, and spatial analysis techniques has introduced novel strategies for elucidating their mechanisms of action