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Patients often report a shift in how their body responds to food and exercise

Antioxidants (Basel) 11, 281

Neither route has been validated in a completed human clinical trial, so both carry significant uncertainty

This is the same principle behind why recombinant protein biologics (monoclonal antibodies, insulin analogues) are never shaken: air-water interfacial agitation unfolds polypeptide chains that then reassemble into non-native oligomers or fibrils