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In addition, further research is needed to clarify potential sex-specific differences and to better understand the central and peripheral mechanisms of action of GLP-1 and amylin analogues, including whether their effects are additive, synergistic, or potentially divergent in different clinical contexts

Stefano GB (2015) Morphine stimulates nitric oxide release in mammalian/human mitochondria

In research settings, GLP-1R agonist peptides are widely used as molecular tools to study incretin biology, energy homeostasis, beta-cell function, and cardiometabolic signaling

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