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DAlessandro M, Kanaan S, Geller M, et al

However, emerging evidence suggests that metabolism, as a canonical stemness marker or signaling pathway, is integral to CSC identity

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Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling