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A clinical study published in JAMA demonstrated that tesamorelin produced a statistically significant reduction in visceral adipose tissue compared to placebo, with concurrent improvements in lipid profiles including triglycerides

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Clinical trials and mechanistic studies suggest they reduce intraglomerular pressure through natriuretic effects, lower albuminuria, and attenuate the progression of diabetic kidney disease by reducing renal oxidative stress and inflammation [9, 10]