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JAMA 2020;323:2397-406.ArticlePubMedPMC 967

Interestingly, a recent study reported a greater exposure to crizotinib and its active metabolite PF-06260182 in subjects with severe renal impairment (creatinine clearance 25%) were increased AST/ALT, lymphopenia, increased ALP, hypocalcemia, neutropenia, thrombocytopenia, hypophosphatemia, and hyperbilirubinemia

Pharmacokinetics in patients with impaired hepatic function study design, data analysis and impact on dosing and labeling

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