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According to Jenna Queller, MD, a board-certified dermatologist and founder of DermWorks in Boca Raton, Florida, Melanotan II is a synthetic peptide designed to mimic alpha-melanocyte-stimulating hormone (also known as -MSH), which she describes as a naturally occurring hormone that stimulates melanocytes, the pigment-producing cells in the skin. By activating these receptors, the peptide can increase melanin production and thus make skin look more tan