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Prokinetic agents and gastric decompression Prokinetic agents such as metoclopramide may be considered in selected clinical contexts, but current evidence is insufficient to rely on them as a predictable solution for GLP-1-associated retained gastric contents

However, evidence also shows that when GLP-1 medications are stopped, many patients regain much of the weight

For patients who have undergone upper gastrointestinal procedures, the oral glucose tolerance test (OGTT) is often poorly tolerated due to the potential for severe dumping syndrome

McGowan says this is likely due to genetic and physiological mechanisms driving excess weight, adding that when stopping these medications, people experience a rapid return of their hunger