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Previously, we identified a systemic dose of the GLP-1R agonist exendin-4 that selectively attenuated the reinstatement of cocaine-seeking behavior in rats 8 , effects mediated, in part, by activation of GLP-1Rs in the ventral tegmental area (VTA) 8

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If cells become resistant to insulin, the blood glucose is stored as fat instead of used for energy, which causes weight gain instead of weight loss