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Psoriasis pathogenesis involves ROS derived from upregulated NOX2/p67phox in keratinocytes, driving metabolic reprogramming via AMPK inactivation and HIF-1 stabilization

While moderate weight reduction is often therapeutically beneficialparticularly in improving metabolic disorders such as type 2 diabetes and obesitysubstantial or prolonged weight loss has been increasingly implicated in adverse skeletal outcomes

Potential for weight regain during the transition

Los GLP-1 (pptidos similares al glucagn tipo 1) son agonistas del receptor GLP-1 , una clase de medicamentos que: Estimulan la secrecin de insulina cuando los niveles de glucosa son elevados Reducen el apetito y retrasan el vaciado gstrico Favorecen la prdida de peso y el control glucmico Han demostrado una gran eficacia en personas con diabetes tipo 2 y, en el caso de Wegovy , tambin en personas con obesidad sin diabetes