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The local mechanisms of these effects are still under investigation, but GLP-1R co-expresses with proteins known to play an important role in appetite, such as prolactin-releasing peptide and tyrosine hydroxylase [42, 43]
Rapid weight loss often leads to significant lean mass loss, which can negatively affect metabolism, bone density, and long term strength
Ongoing research studies are testing the medication for obstructive sleep apnea (OSA), knee osteoarthritis (OA), non-alcoholic fatty liver disease (NAFLD), and cardiovascular risk reduction
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