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The superoxide anion and other ROS can harm organisms by damaging genetic information, oxidizing proteins, or initiating lipid peroxidation
10.1016/j.biopha.2020.110985 7 ChaoJ.ChengH
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The first is that the longest I-helix in the CYP450 molecule is broken up into two parts, the N-terminal part pulling away from the center of the molecule, and the other is the position of the B-C loop at the top of the molecule producing an open substrate access channel [25]
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