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doi: 10.3389/fnins.2025.1576773 Received 14 February 2025 Accepted 08 April 2025 Published 23 April 2025 Volume 19 - 2025 Edited by Matilde Otero-Losada, National Scientific and Technical Research Council (CONICET), Argentina Reviewed by Lefteris Zacharia, University of Nicosia, Cyprus Da Sun, Wenzhou University, China Shubham Upadhayay, Central University of Punjab, India Updates Copyright 2025 Wang, Zhang and Zhai

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It does not promote GH synthesis, so pairing it with a GHRH (e.g., CJC-1295, Sermorelin, Tesamorelin) is essential for full GH-axis stimulation Works best with consistent use over a period of time (chronic dosing has shown more stable results compared to short bursts)

Thus, choline is considered to be an essential nutrient for humans (81)