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Cost and side effects are the most common reasons people discontinue treatment

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These include serious allergic reactions, potential liver and kidney damage, and, in some cases, even life-threatening complicationsespecially when administered without proper medical supervision or outside of clinical environments

In one study, it affected Egr , Nos , Srf , Vegfr , Akt1 , Plc, and Kras gene expression in the vessel that provides an alternative operating pathway (i.e., the left ovarian vein as the key for infrarenal occlusion-induced inferior vena cava syndrome in rats) (Vukojevic et al., 2018)