NNMT is expressed at high levels in the liver and is also present in adipose tissue, kidney, brain, lung, heart, and skeletal muscle
48 weeks (titration + maintenance) 8-10 vials Maintenance draws of 240 units use ~16% of a vial per week
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The perfusion-limited distribution model well describes drugs with rapid tissue distribution ( 2 ) and the rapid brain distribution observed in adult mice after an oral 7,8-DHF dose (Liu et al., 2013
