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Secretome engineering is an emerging frontier: PD-MSCs primed to secrete high hepatocyte-growth-factor engage Wnt/-catenin signalling to tighten endothelial barriers and foster follicular growth [183], while an estrogen-responsive PD-MSC secretome rescues cyclophosphamide-induced POI, restores circadian clock genes and curbs granulosa-cell apoptosis, suggesting cell-free formulations could combine ovarian repair with systemic chronoprotection [20]

These materials also demonstrate low haemolytic activity, favourable in vivo biosafety, and localised tumour accumulation via L-type amino acid transporter 1-mediated uptake, enabling improved drug delivery with reduced systemic toxicity [188]

6,7 Functional brain imaging suggests that this aberrant processing may be attributed to an imbalance between excitatory and inhibitory neurotransmitters, particularly within the insula

Chen W, Thiboutot D, Zouboulis CC