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They showed that biologically active IGF-488 (IGF-1 conjugated with Alexa Fluor 488) entered the growth plate and localized to chondrocytes [241]

Therefore, although oxidants play key roles in pathogen killing and resolution of inflammation, oxidative stress caused by cigarette smoke and macrophage activation contributes to the pathophysiology of COPD by creating a vicious circle that is difficult to stop once started (Figure 2)

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