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The active ingredient in these medications is semaglutide, which works in the brain to impact satiety

through mitochondrial ROS-mediated SERCA2a oxidation, it reduces ATPase activity, causing reduced systolic Ca 2+ release and diastolic Ca 2+ leakage, triggering arrhythmias (Tamayo et al., 2020)

The climbing demand for these drugs driven by expanded indications and increasing off-label use for cosmetic weight loss, led to insurmountable shortages on the market