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(1997) demonstrated that IGF-1-mediated PI3K/Akt signaling plays essential roles in myoblast differentiation models, with IGF-1 LR3 serving as the preferred growth factor due to its predictable dose-response characteristics

Neohesperidin (NHP) can inhibit macrophage migration into target tissues and decrease pro-inflammatory cytokine levels, including TNF-, IL-1, IL-6, and COX-2, at both mRNA and protein levels, exceeding that of mesalazine at similar concentrations (173)

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