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Novo Nordisk, a competitor to Eli Lilly, has already sought FDA approval for an oral semaglutide pill, its oral GLP-1 pill, and is expected to receive a decision by the end of this year

Lower melatonin doses (1.5 mg/kg/day) in a mouse model of AD (Tg2576) showed no significant modification of brain APP immunoreactivity compared to non-treated animals [165], emphasizing the need to determine efficacious doses

However, a needed framing of this question is not whether GLP-1 medications induce SMM loss at all, but rather does greater SMM loss occur as compared to the normal degree of SMM loss that occurs with other weight loss interventions