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Limitations include the restricted choices of E3 ligases, primarily CRBN and VHL, and the considerable molecular weight of compounds that cause poor BBB penetration

-EC and GSH standards and UDE enhanced SH-SY5Y intracellular GSH content In our previous investigation, we identified the protective effect of a 4 h incubation with 100 M of -EC, GSH, or UDE containing 100 M -EC against oxidative damage caused by H 2 O 2

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Additionally, we also investigated the glucagon secretion using perfused GCGR-KO pancreatic islets