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Methods: This multicenter retrospective cohort study evaluated adult patients with T2DM and ESRD, including those receiving maintenance hemodialysis, who were prescribed injectable semaglutide between January 2016 and July 2025 at tertiary care centers in Saudi Arabia

It is best for longevity-focused, self-directed patients who are comfortable with medium support levels and want GLP-1 therapy as part of a broader anti-aging protocol

Renal Elimination Primarily excreted unchanged by the kidneys

The multivalency of the dimeric peptide structure contributes to the notable ROS-scavenging efficacy of G/D-CuP, confirming its great antioxidant capacity