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Sixteen weeks of running wheel exercise upregulate the expression of adiponectinreceptor1 (AdipoR1) protein in the skeletal muscle of aged mice, promotes its downstream proteins transcriptional activity, forkhead box class O3 (FOXO3) to increase FOXO3a protein levels, which in turn upregulates LC3-II and BNIP3 protein expression, downregulates p62/SQSTM1 protein levels, and increases the mRNA expressions of Beclin1, ULK1, recombinant phosphoinositide-3-kinase class 3 (Pik3c3), ATG5, ATG7, LC3B, BNIP3, and PINK1

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The physiological or therapeutic significance of GLP-1 RA engagement at these peripheral sites remains unclear and warrants further investigation