An important role is to inactivate incretins (GLP-1 & GIP)
Although the FDA has issued a boxed warning for semaglutide, based on animal studies indicating a risk for thyroid C-cell tumors [48], no target-organ toxicity emerged, and there was no signal for thyroid C-cell hyperplasia, an observation later corroborated in clinical trials
In the event of BD, obtained results are more limited than in other psychiatric disorders, although some authors argue that because of the nature of BD and its therapy, the field of epigenetics can be critical for understanding the clinical course of this complex disorder, aiding to define the role of environmental factors, and the possible identification of promising state and traits biomarkers [25]
However, the kinetic patterns do not support a ping-pong mechanism and the nonenzymatic first reaction with a second order rate constant of 0.6 M 1 s 1 is too slow to explain the rapid turnover 3,12,14,15,30