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[DOI] [PubMed] [Google Scholar] 122.Schijns W., Homan J., van der Meer L., Janssen I.M., van Laarhoven C.J., Berends F.J., Aarts E.O

Vitamin B12 is necessary for various bodily functions

A 2021 peer-reviewed review of NNMT in obesity and type 2 diabetes states explicitly that 'clinical trials targeting NNMT have not been reported' meaning every quantitative efficacy figure available for this compound comes from mice, and there is currently zero published human efficacy data

The glucose-lowering effect proved so robust that tirzepatide earned FDA approval for type 2 diabetes management before its weight loss indication