Beth, for one, is considering stopping the drug for this reason
Sixty male, 5-wk old, wild-type C57BL/6J mice (JanVier Labs, France) were group housed in a controlled environment (12 h lightdark cycle, 21 2 C, 50 10% humidity) and fed the AMLN diet high in trans-fat, cholesterol, and fructose 46 ad libitum for 32 weeks to induce obesity and the NASH phenotype
And then there was another component to it where what we defined as risk premia, I suppose
Estrogen Metabolism Support Optimizing hepatic Phase I and Phase II estrogen detoxification reduces the burden of potentially carcinogenic estrogen metabolites (particularly 4-OH and 16-OH estrone) and may reduce estrogen-driven fibroid growth: DIM (diindolylmethane): Shifts estrogen metabolism toward the favourable 2-OH pathway Calcium-D-glucarate: Inhibits -glucuronidase, preventing deconjugation and reabsorption of estrogens in the gut (Note: off-the-shelf detox kits from health food stores are not equivalent to therapeutic doses of these specific compounds) N-acetylcysteine (NAC): Supports glutathione synthesis and Phase II sulphation 3
