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The decision to add B12 is made by individual prescribers working with compounding pharmacies, which is why B12 only appears in compounded formulations

Important Safety Information Contraindications and Precautions: Joint injections should only be performed by qualified medical professionals Active joint infection is an absolute contraindication to intra-articular injection Bleeding disorders or anticoagulation therapy may increase injection risks Pregnancy and breastfeeding: no safety data available, avoid use Cancer history: while AOD-9604 does not affect IGF-1, consult oncologist before use Monitoring Recommendations: Regular follow-up with joint imaging and functional assessments to evaluate treatment response

doi: 10.1038/ejcn.2014.165

It can boost energy and improve mood, especially if you have a deficiency