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Different parameters could modulate tolerance such as the opioid agonist used (Enquist et al., 2012), duration of treatment (Soignier et al., 2004), doses (Huidobro et al., 1976) and even the pharmacological effect observed (Mohammed et al., 2013)

It plays a crucial role in maintaining redox homeostasis in lung tissue and contributes to glutathione synthesis

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