tirzepatide weight loss vs semaglutide efficacy of versus in achieving therapeutic targets in type 2 diabetes: a post hoc analysis of the SURPASS-2 Trial | Diabetologia Mazdutide vs Tirzepatide vs Semaglutide:

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Tirzepatide activates both GLP-1 and GIP receptors, sometimes causing slightly higher rates of nausea and gastrointestinal effects than semaglutide alone, particularly at higher doses

It can spread into your lymph nodes and is also more likely to spread into your blood vessels