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Rats were bred in-house at the Animal Pharmacology Facility, School of Medicine, Zagreb, Croatia

The latter regulates the Nrf2-ARE pathway mainly through phosphorylation sites and is considered a critical regulatory factor of Nrf2 nuclear accumulation, nuclear rejection, and degradation

The compound suppresses lipogenesis in a concentration-dependent manner, with doses of 30-60 M reducing lipid accumulation by 50-70% in cultured adipocytes

For instance, high doses of vitamin E supplementation have been linked to an increased risk of prostate carcinoma, and long-term -3 PUFAs (-3 polyunsaturated fatty acids) supplementation may be associated with serious side effects [12]