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Even at low doses, side effects can still occur, and inadequate dosing may blunt the therapeutic effects

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however, their path from the laboratory to the clinic encounters notable hurdles ( 4.3 The critical need for biomarkers of brain ferroptosis in vivo The advancement of ferroptosis-targeted therapies in clinical trials is hampered by a critical bottleneck: the absence of validated, non-invasive biomarkers to directly detect and monitor ferroptosis within the brains of living patients