15 Months of Progress After 15 months of consistent treatment with Tirzepatide at a dose of 7.5 mg/week, JHs results were nothing short of inspiring: Follow-Up Bioimpedance Spectroscopy Measurements: Weight: 162 lbs (a 78-lb loss) Body Fat Percentage: 32.9% (down 12.8%) BMI: 23.3 (a reduction of 10.1 kg/m) Body Fat Mass: 53.2 lbs (a decrease of 56 lbs) Lean Body Mass: 109 lbs (down 21 lbs) Skeletal Muscle Mass: 59 lbs (loss of only 12 lbsjust 15% of her total weight loss, less than the typical 20%) ECW/TBW: Slight improvement in the right leg to 0.396
Protocol 1: standard tirzepatide protocol Goal: Achieve 15-20% body weight reduction over 6-12 months Dose escalation: Weeks 1-4: 2.5mg subcutaneous injection once weekly Weeks 5-8: 5mg once weekly Weeks 9-12: 7.5mg once weekly (optional, can skip to 10mg) Weeks 13-16: 10mg once weekly Weeks 17-20: 12.5mg once weekly Week 21+: 15mg once weekly maintenance Administration: Inject subcutaneously in abdomen, thigh, or upper arm Rotate injection sites to prevent injection site reactions Best administered on the same day each week Store properly per tirzepatide storage requirements Nutritional support: Minimum 100-120g protein daily (see tirzepatide diet planning ) Avoid high-fat, greasy foods during escalation (check foods to avoid list ) Stay hydrated, minimum 64oz water daily Consider targeted supplementation including multivitamins, omega-3s, and B12 Expected timeline: Weeks 1-4: Appetite suppression begins, 1-3% weight loss Weeks 5-12: Noticeable results, 5-8% weight loss Weeks 13-24: Significant changes, 10-15% weight loss Weeks 25-52: Approaching maximum benefit, 15-20%+ weight loss Protocol 2: retatrutide research protocol Goal: Achieve 20-28% body weight reduction over 6-12 months Dose escalation: Weeks 1-4: 1mg subcutaneous injection once weekly Weeks 5-8: 2mg once weekly Weeks 9-12: 4mg once weekly Weeks 13-16: 8mg once weekly Week 17+: 12mg once weekly maintenance Administration: Inject subcutaneously following standard retatrutide injection technique Optimal injection sites described in the retatrutide injection site guide Store refrigerated, reconstituted vials have limited stability (see retatrutide shelf life ) Reconstitute with bacteriostatic water per reconstitution chart Important monitoring: Track resting heart rate weekly (the glucagon receptor can elevate HR) Monitor liver enzymes if MASLD is present Track body composition changes, not just scale weight Assess GI tolerance at each dose increase, slow escalation if needed Expected timeline: Weeks 1-4: Mild appetite effects at initiation dose Weeks 5-12: Progressive appetite suppression, 5-10% weight loss Weeks 13-24: Significant metabolic effects, 12-18% weight loss Weeks 25-48: Approaching maximum benefit, 20-28%+ weight loss Protocol 3: transitioning from tirzepatide to retatrutide Goal: Safely switch between compounds while maintaining weight loss momentum This protocol is specifically for researchers who have been on tirzepatide and want to transition to retatrutide, typically because of a plateau or desire for additional metabolic benefits
Step 1 Eligibility Pre-Screen Youll provide: BMI Age Basic contraindication check Takes about 2 minutes and provides immediate feedback if youre not a candidate
8 mg weekly (32 mg total per vial)
