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The broader picture is one in which MOTS-c addresses a gap that many other longevity interventions leave unfilled: the mitochondrial signaling decline that is simultaneously a cause and consequence of metabolic aging

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( In the context of ocular diseases, iron-dependent lipid peroxidation and ferroptosis have been linked to various retinal pathologies, including age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy