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This designation allows use of these compounds for in-vitro laboratory testing and experimentation only

In a review of 18 studies, eleven trials reported a positive effect of B vitamins on improving overall mood or a facet of mood, with the most significant benefits to stress

Early clinical diagnosis followed by empirical treatment shows superior cost-effectiveness compared to strategies requiring surgical confirmation in most healthcare economic analyses (Brown & Farquhar, 2014)

What would move this position is: a randomised, placebo-controlled trial in a defined population with an objective primary endpoint, a pre-registered protocol, and pharmacovigilance over a clinically meaningful duration