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The terms used for the research were DPP-4 inhibitors, GLP-1 receptor agonists, SGLT-2 inhibitors, MACE, heart failure, renal outcome, total death cardiovascular death and their synonyms and related keywords

FDA-approved options include Wegovy (semaglutide), Zepbound (tirzepatide), Saxenda (liraglutide), Contrave (naltrexone/bupropion), Qsymia (phentermine/topiramate), and orlistat

134 Recently, Fortin et al 135 evaluated the effects of liraglutide in both NTS AAV-shRNA-driven Glp1r knockdown and AP-lesioned animals, and used fluorescence in situ hybridization to detect Glp1r transcripts in NTS GABAergic neurons