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Taking biotin with food and starting with lower doses can minimize these issues

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In an in vitro model of pancreatic islet INS-1 cells in PA-treated rats, SENDs increase mRNA expression of GPX1, enhance the level of Parkin/PINK1-mediated mitophagy, downregulate GRP78, PERK, eIF-2, and CHOP expression, and inhibited ERS and apoptosis, thereby maintaining the numerical and functional stability of pancreatic islet cells ( Activation of mitophagy alleviates insulin resistance and OS and improves T2DM