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8.2 Cost-effectiveness and health economic implications The elevated cost of acquisition of GLP-1 receptor agonists convey major challenges for healthcare systems, with yearly treatment expenses between $10,000 and $15,000 USD, markedly surpassing those of conventional diabetic drugs (Kong et al

However, more recent evolutionary coevolution analyses and microscopy work demonstrate that ZnT9 predominantly localizes to mitochondria and functions as a zinc exporter, with loss leading to mitochondrial zinc overload and dysfunction 39

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