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Regulation of immune response GLP-1s can suppress or balance immune response through key cells involved in inflammatory skin disease, including the T lymphocytes that drive plaque formation in psoriasis and eczema, and iNKT cells active in the autoimmune system

Discontinuation rates due to adverse events (12.2% and 18.2% vs 4.0% with placebo) were highly correlated with baseline BMI and included discontinuations for perceived excessive weight loss

Because of the significant risks associated with compounded tirzepatide, the FDA strongly recommends using an FDA-approved tirzepatide drug like Zepbound or Mounjaro when it is available