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"Everything that comes fast, goes fast," she says, noting that she started seeing a nutritionist and working out, and has since been able to start losing the weight again

The acquired resistance to ICB treatment might be due to cancer cell-intrinsic and -extrinsic changes, including the loss of MHC class I on cancer cells (175, 176), genetic mutations that diminish T-cell infiltration (177, 178), or host microbiota (179182)

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Absence of LTB4/BLT1 axis facilitates generation of mouse GM-CSFinduced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems