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Role of glycocalyx in SAP-associated multiple organ dysfunction The pathogenesis of SAP is complex and involves intracellular inflammatory pathways, enzyme activation, endotoxemia, and vascular endothelial damage (Table 3)

These findings suggest that NDP-alpha-MSH may be of research interest in the context of organ transplantation by influencing heart function through its broad effect on multiple pathways, including both Ag-dependent and -independent injury

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