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Despite lowering inflammation, we did not have the corresponding benefit on cognition that we had hoped for. Nathaniel Chin, medical director of the Wisconsin Alzheimers Disease Research Center, told Being Patient that even though we think of the brain and the rest of the body as connected, these findings show that a reduction in inflammation throughout the body doesnt necessarily translate to the brain

Similarly, knockdown of TMLHE decreased multiple histone acetylation marks, many of which were rescued by l-carnitine (Extended Data Fig

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Increased TMAO levels in the bloodstream encourage lipid accumulation in the arteries, which contributes to atherosclerosis